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A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase

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It is a negative feedback response mechanism to chronic changes in the level of network activity, in which the synaptic strengths of a neuron are modified by regulating synaptic receptors following a universal multiplicative scaling factor [18] [14] This effect occurs gradually over hours or days, by changing the numbers of NMDA receptors at the synapse (Prez-Otao and Ehlers, 2005)